PRODUCT DESCRIPTION

India has one of the highest rates of metabolic disease in the world – and the nutritional gap driving it has a well-researched solution.

Berberine+ by The 5XL Nutrition is formulated around Berberine Hydrochloride – one of the most clinically studied plant alkaloids in modern metabolic research, documented across decades of peer-reviewed trials for its effects on blood glucose, insulin sensitivity, lipid metabolism, gut microbiome composition, and cardiovascular markers. At 500mg of Berberine HCL per serving – the clinically studied dose – enhanced with Chromium for insulin receptor support and Black Pepper Extract (Piperine) for significantly improved bioavailability, Berberine+ is the most complete berberine formula available in India.

Available at ₹1,311 (25% off ₹1,749) for 60 capsules – 30 days at the full clinical dose – with free shipping pan-India. Vegetarian capsules, GMP certified. Verify at the5xlnutrition.com/verify-product before your first dose.

Berberine+ is a nutritional supplement – not a medicine. If you have diabetes or are taking blood sugar medications, consult your doctor before use.

Why Choose The 5XL Nutrition Berberine+?

Formulated for genuine metabolic impact – not an under-dosed capsule. Here’s what sets it apart:

500mg Berberine HCL – The Clinically Studied Dose: Many low-cost berberine products use 200-300mg – falling short of the doses used in clinical research. Berberine+ delivers 500mg of Berberine Hydrochloride (HCL), the salt form with the best intestinal solubility, matching the dose used in the human trials that established berberine’s metabolic effects.
Black Pepper Extract (Piperine) – 2-3× Improved Absorption: Piperine inhibits the intestinal and hepatic metabolism of berberine before it reaches systemic circulation – significantly increasing how much active berberine reaches your cells per dose. This is the single most important formulation decision that separates an effective berberine supplement from an ineffective one.
Chromium – Insulin Receptor Co-Factor: Chromium deficiency is surprisingly common in Indian diets high in refined carbohydrates and directly impairs insulin sensitivity. Berberine+ includes Chromium to enhance insulin receptor signalling at the cell membrane – working synergistically with berberine’s intracellular AMPK mechanism.

Key Benefits of Berberine+

Supports Healthy Blood Glucose Regulation: Berberine activates AMPK in liver and muscle cells, reducing hepatic glucose output and improving peripheral glucose uptake – resulting in more stable post-meal blood glucose and reduced fasting glucose variability. Documented across multiple human clinical trials.
Improves Insulin Sensitivity: AMPK activation enhances the cellular response to insulin – less insulin is required to achieve the same glucose-lowering effect. Chromium further supports this by optimising insulin receptor signalling at the membrane level.
Supports Healthy Lipid Metabolism: Berberine research consistently shows improvements in total cholesterol, LDL, and triglycerides through AMPK-driven suppression of hepatic fat synthesis and improved LDL receptor clearance.
Supports Fat Loss and Body Composition: AMPK activation enhances fatty acid oxidation (fat burning) while reducing lipogenesis (fat synthesis). Clinical trials have documented reductions in visceral adiposity with berberine supplementation, particularly alongside diet and exercise.
Improves Gut Microbiome Composition: Berberine reaches the lower intestine where it selectively modulates gut bacteria – increasing beneficial Lactobacillus and Bifidobacterium species while reducing pathogenic populations, supporting both metabolic and digestive health.
Beneficial for Women with PCOS: Insulin resistance is a central driver of PCOS. Multiple clinical trials have evaluated berberine specifically in PCOS, finding improvements in menstrual regularity, androgen levels, and insulin sensitivity. Consult your doctor before use for PCOS management.

Nutritional Information (Per serving)

Nutrients	Amount Per Serving	%RDA*
Energy	0kcal	–
Carbohydrates	0g	–
Protein	0g
Total Fat	0g	–
Cholesterol	0g
Sodium	0mg
Berberine Hcl 95%	500mg	–
Milk Thistle Extract	250mg	–
Cinnamon powder	100mg	–
Chromium Picolinate	100mcg	–
Alpha-Lipoic Acid (ALA)	50mg	–
Fenugreek Extract	50mg	–
Gymnema Sylvestre Extract	50mg	–
Vitamin D3	500Iu	83
Zinc (as Zinc Citrate)	10mg	83
Magnesium (as Magnesium oxide)	100mg	22

How to Use Berberine+

Take 1 veg capsule twice daily – 30 minutes before your two largest meals (typically breakfast and dinner). Split dosing maintains more consistent berberine blood levels throughout the day, as berberine has a short plasma half-life of approximately 2-4 hours. This is the dosing protocol used in the majority of clinical research.

For the first week, start with 1 capsule daily to allow your gut to adjust, then increase to the full 2-capsule dose
Best taken before meals containing significant carbohydrates – when berberine’s blood glucose effects are most relevant
Stack with Milk Thistle or Liver King from the 5XL range for combined metabolic and liver support

What to expect: Weeks 1-2: Reduced post-meal energy crashes and improved digestive comfort. Weeks 2-3: More consistent energy and reduced hunger between meals. Weeks 4-6: Measurable fasting glucose improvements and modest body composition changes. Weeks 8-12: Peak metabolic benefit – most meaningful HbA1c improvements alongside diet and exercise.

FAQs

What is the price of Berberine+ and how long does one bottle last?

₹1,311 – 25% off MRP of ₹1,749. Each 60-capsule bottle is a 30-day supply at the recommended 2 capsules per day. Free shipping pan-India from the5xlnutrition.com.

What do Berberine HCL + Chromium + Black Pepper Extract do together?

Three distinct mechanisms working synergistically: Berberine HCL activates AMPK – reducing hepatic glucose output and improving insulin sensitivity. Chromium enhances insulin receptor signalling at the cell membrane. Piperine inhibits berberine’s intestinal metabolism, significantly increasing how much active berberine reaches systemic circulation with each dose.

Can Berberine+ replace diabetes medication like Metformin?

No. Berberine+ is a nutritional supplement – it cannot replace prescribed diabetes medication. If you have diagnosed type 2 diabetes or are on antidiabetic medication, consult your doctor before use. Adding berberine to diabetes medication without supervision may cause blood glucose to drop too low.

Is Berberine+ suitable for women with PCOS?

Berberine has been specifically studied in PCOS across multiple clinical trials, with findings suggesting improvements in insulin sensitivity, menstrual regularity, and androgen markers. Consult your gynaecologist or endocrinologist before adding Berberine+ to your PCOS management plan.

Are there any side effects?

The most commonly reported effects are mild and gastrointestinal – nausea, cramping, or loose stools – typically during the first 1-2 weeks as the gut microbiome adjusts. Start with 1 capsule daily for the first week before increasing to the full dose to minimise discomfort

How do I verify my Berberine+ is genuine?

Every bottle includes a unique authenticity code. Visit the5xlnutrition.com/verify-product and confirm in under 30 seconds. Berberine supplements are frequently under-dosed in the Indian market. Always verify before your first capsule.

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